"Brown disgusting fluid" was seen filling sinks in one of the region's main hospitals.
The fluid was seen spilling over at the James Paget Hospital's ambulatory care unit today.
Hospital bosses said two sinks overflowed in the unit as a result of problems in the ward above.
A witness said they heard a "loud grumbling and bubbling sound" and dashed to the reception to report it.
They added: "You could see it coming out of the door into the main reception floor.
"Maintenance men appeared quickly with people putting large pads and towels to try to contain the mess."
A spokeswoman for the James Paget said: “This morning, Wednesday 16 October, our estates team received a report of a blockage in a sink in a ward directly above the hospital’s ambulatory care unit.
"While the team were dealing with this blockage they took a report that two sinks were overflowing in the ambulatory unit, which shares waste pipework with the ward above.
“Additional staff from the estates team attended, the immediate area was temporarily closed off, and, after accessing below ground drainage, the blockage was cleared.
"After tests to ensure the sinks were working correctly again, the area was deep cleaned by our domestic team and returned to normal use early this afternoon.”
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The ambulatory unit is "designed for the rapid assessment and treatment of medical problems which can be managed without the need for an overnight stay".
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